Host defenses against Staphylococcus aureus infection require recognition of
bacterial lipoproteins
Message: 2
Date: Wed, 06 Sep 2006 16:08:58 +0000
From: <[email protected]>
Subject: Sludge Watch ==> Some S. aureus escape immune recognition
thus cause infections
To: [email protected]
Message-ID: <[email protected]>
Content-Type: text/plain; format=flowed
Sludgewatch Admin:
Hmmm...just why are so many people near sludge sites getting S.aureus
infections?
I wonder if the sewage treatment plant generates S.aureus mutations that
then escapedetection by the human immune system.
........................................................................
Host defenses against Staphylococcus aureus infection require recognition of
bacterial lipoproteins
04.sep.06
PNAS Online
Proceedings of the National Academy of Sciences (PNAS)
Juliane Bubeck Wardenburg et al
http://www.pnas.org/cgi/content/abstract/0603072103v1
Toll-like receptors and other immune-signaling pathways play important roles
as sensors of bacterial pattern molecules, such as peptidoglycan,
lipoprotein, or teichoic acid, triggering innate host immune responses that
prevent infection. Immune recognition of multiple bacterial products has
been viewed as a safeguard against stealth infections; however, this
hypothesis has never been tested for Staphylococcus aureus, a frequent human
pathogen.
By generating mutations that block the diacylglycerol modification of
lipoprotein precursors, we show here that S. aureus variants lacking
lipoproteins escape immune recognition and cause lethal infections with
disseminated abscess formation, failing to elicit an adequate host response.
Thus, lipoproteins appear to play distinct, nonredundant roles in pathogen
recognition and host innate defense mechanisms against S. aureus infections.